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Human Research Protection


View each of the YouTube clips listed below:

https://www.youtube.com/watch?v=Rz8ge4aw8Ws Caring Corrupted: The Killing Nurses of the Third Reich

https://www.youtube.com/watch?v=-O5gsF5oyls   Research Ethics

https://www.youtube.com/watch?v=86zWBjDaXPk    Belmont Report Part 1

https://www.youtube.com/watch?v=cIafASIIU70    Belmont Report Part 2

https://www.youtube.com/watch?v=iFik0of3iUM    IRB   (Institutional Review Board)

After viewing each video, write two paragraphs about each video describing the purpose of the video and discuss one point from each video that you think is important regarding protecting human subjects in research and provide a rationale. Your submission should be 400-500 words, using APA style.

Respiratory Clinical Case Patient Setting: 65 year old Caucasian female that was discharged from the hospital 10 weeks ago after a motor vehicle accident presents to the clinic today. States she is having severe wheezing, shortness of breath and coughing at least once daily. She can barely get her words out without taking breaks to catch her breath and states she has taken albuterol once today. HPI Frequent asthma attacks for the past 2 months (more than 4 times per week average) , serious MVA 10 weeks ago; post traumatic seizure 2 weeks after the accident; anticonvulsant phenytoin started – no seizure activity since initiation of therapy. PMH History of periodic asthma attacks since early 20s; mild congestive heart failure diagnosed 3 years ago; placed on sodium restrictive diet and hydrochlorothiazide; last year placed on enalapril due to worsening CHF; symptoms well controlled the last year. Past Surgical History None Family/Social History Family: Father died age 59 of kidney failure secondary to HTN; Mother died age 62 of CHF Social: Nonsmoker; no alcohol intake; caffeine use: 4 cups of coffee and 4 diet colas per day. Medication History Theophylline SR Capsules 300 mg PO BID Albuterol inhaler, PRN Phenytoin SR capsules 300 mg PO QHS HTCZ 50 mg PO BID Enalapril 5 mg PO BID Allergies NKDA ROS Positive for shortness of breath, coughing, wheezing and exercise intolerance. Denies headache, swelling in the extremities and seizures. Physical exam BP 171 /94, HR 1 22 , RR 31, T 96.7 F, Wt 145 , Ht 5’ 3” VS after Albuterol breathing treatment – BP 134/79, HR 80, RR 18 Gen: Pale, w ell developed female appearing anxious . HEENT: PERRLA, oral cavity without lesions, TM without signs of inflammation, no nystagmus noted . Cardio: Regular rate and rhythm normal S1 and S2 . Chest: Bilateral expiratory wheezes . Abd: soft, non -tender, non -distended no masses . GU: Unremarkable . Rectal: Guaiac negative . EXT: +1 ankle edema, on right, no bruising, normal pulses . NEURO: A&O X3 , cranial nerves intact. Laboratory and Diagnostic Testing Na – 134 K – 4.9 Cl – 100 BUN – 21 Cr – 1.2 Glu – 110 ALT – 24 AST – 27 Total Chol – 190 CBC – WNL Theophylline – 6.2 Phenytoin – 17 Chest Xray – Blunting of the right and left costophrenic angles Peak Flow – 75/min; after albuterol – 10 2/min FEV1 – 1.8 L; FVC 3.0 L, FEV1/FVC 60%

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