Over a long time, as depicted from the article, the whole-body skeletal x-ray survey (WBXR) has been used as the imaging technique for myeloma bone lesion (Dyrberg et al., 2017). The article, however, acknowledges that there are new techniques developed with improved technology. The new methods include whole-body magnetic resonance imaging (WB-MRI), 18f-sodium fluoride (NAF) PET/CT and 18f-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). The purpose of the paper is to compare the whole-body skeletal X-ray survey (WBXR) and the new technology methods. The research question that this article critique answers is the determination of the effectiveness of the various technology techniques in in imaging for myeloma bone lesion.
The article suggests that in a region-based analysis, a two-sided ANOVA test indicates that the degree of the identified skeletal disease relies on the used scanning technique. According to the multiple comparison test conducted in Turkey, the outcome suggests that the WB-MRI detects more elaborate results on the affected region in comparison to the other methods including WBXR, FDG-PET/CT and NAF-PET/CT. According to a patient-based analysis, a Cochran’s Q test suggested that there no noticeable difference in the proportion of patients with myeloma bone diseases exhibited by various techniques of scanning (Dyrberg et al., 2017). Following the study conducted, the WB-MRI imaging technique realized, on average, significantly increased regions indicative of myeloma bone in comparison to all the other methods used in the patients. The study consequently considerers the WB-MRI imaging technique as the most favourable imaging technique to be utilized in the care of newly diagnosed myeloma patients. The results of the study suggest that it presents the best method for the generation of highly effective results.
The evidence presented by the paper is sufficient in arguing the case for the efficiency of the various methods and techniques utilized in the scanning of the imaging technique for myeloma bone lesion. Adequate evidence is generated from the fact that in the study, a significant number of patients was used for the study sample. The survey uses a total of fourteen patients with myeloma bone lesion to determine the efficiency of the various imaging techniques. The elaborate number works efficiently in the generation of adequate evidence through the provision of the points of reference. Through the use of a significant number of patients, the results generated provide sufficient evidence as they are used for comparison purposes.
There are various strengths and weaknesses presented in the study. Among the strengths of the survey entail the use of an elaborate study population. The survey uses a study population of a total of fourteen people (Dyrberg et al. 2017). Through the detailed number, the research can compare the results as generated from the fourteen participants to determine the best method to use. The other strength of the research is that all the identified methods are used on the same patients. As a result, the result generated can be easily evaluated using the same tests on the same people suggests that the results generated are comprehensive as the sample is the same.
Other than the strengths presented in the paper, there are also weaknesses identifiable in the study. Among the weaknesses in the study include that the results of the study only focus on the assessment of the WB-MRI methods against the other methods, including FDG-PET/CT and NAF-PET/CT. The research fails to evaluate the strengths of the other methods, including WBXR, FDG-PET/CT and NAF-PET/CT. Following the generated results, the determination of the strengths of the other methods of study requires the performance of another study, which would then be time-consuming. Another weakness of the study is that all samples were collected at the same place. The study was also conducted at a single point over a short period. As a result, the results presented by the study are not efficiently generalizable as the study covers a very small population.
The study utilizes statistical analysis in the determination of the results. The study depended on a set of equations in the determining the efficiency of the various methods of testing. The statistical value presented elaborated the P-value < 0.05 as the level of significance. The evaluation of the statistical data of the study relied upon the set value of P. All the statistics collected in the study were consequently evaluated against the statistical equation to generate a statistic that could be compared efficiently for studies purposes. Additionally, through the use of the two-sided ANOVA test, the results suggest that the extent of bone disease depends on the scanning technique represented as. P < 0.0001. the other P value presented in the study suggests that WB-MRI detected more affected regions in comparison to WBXR (P < 0.005), FDG-PET/CT (P < 0.0001), and NaF-PET/CT (P < 0.05).
A true negative as presented in the study suggests that entail that not all WB-MRI and PET/CT were obtained on the exact scanner and with the precise scanning protocol during the entire period. false negative presented in the study suggests that as a result of the small number of participants in the study, there was the lack of sufficient patient-based analysis. A true positive presented in the study suggest that recruitment of the study participants was significantly low as a result of the lack of the low disease incidence suffering from the disease. A false positive in the study suggest that most myeloma patients willingly initiate steroid therapy as a result of their clinical conditions.
In conclusion, the article elaborating on the use of other methods and imaging technique for myeloma bone lesion is essential in the creation of a change in nuclear medicine. Through the article, there is an elaborate analysis of other techniques other than the whole-body skeletal X-ray survey, which has been the primary method utilized over a long period. Following the analysis of the research, it is possible to determine other more essential methods in the imaging of the technique for myeloma bone lesion. The study is further essential as it brings out WB-MRI as the best imaging technique and information that would be essential in the shaping of nuclear medicine. The study further shapes the future of nuclear medicine through shaping the future of the subsequent studies to determine the efficient imaging technique to utilize for the myeloma bone lesion.
Dyrberg, E., Hendel, H. W., Al-Farra, G., Balding, L., Løgager, V. B., Madsen, C., & Thomsen, H. S. (2017). A prospective study comparing whole-body skeletal X-ray survey with 18F-FDG-PET/CT, 18F-NaF-PET/CT and whole-body MRI in the detection of bone lesions in multiple myeloma patients. Acta radiologica open, 6(10), 2058460117738809.